Background Opioid Treatment

Background opioid treatment, which provides pain coverage during the entire 24-hour day, must closely follow titration rules and be given on a regular schedule to avoid any breaks in treatment.

Titration aims to progressively increase (or reduce) the optimal opioid dose to provide effective and well tolerated analgesia.

Clinical experience in palliative care has shown that the optimal dose cannot be determined in advance.

It must be personalized for each patient, and strike a balance between under-dosing, thus not providing sufficient pain relief, and over-dosing, which could lead to opioid intoxication and be fatal.